Mame Dennis, a progressive and independent woman of the 1920s, is left to care for her nephew Patrick after his wealthy father dies. Mr. Babcock, Patrick's assigned executor, objects to Mame's unconventional way of living and tries to force her to send Patrick to prep school. As Mame and Patrick grow closer, Mr. Babcock tries to discipline Patrick and threatens to separate the two if Mame does not comply with his wishes.

The author relates important common-sense lessons learned from his elderly aunt about work, family, politics, health care, and traditional values.